Bone Health in PCOS Is the hard tissue softened A Translational Research View

Bone Health in PCOS:
Is the hard tissue softened?
A Translational Research View

Miralireza Takyar, MD PhD

Physician-Scientist Resident n Internal Medicine and Endocrinology

Endocrine Research Center

Research Institute for Endocrine Sciences

Shahid Beheshti University of Medical Sciences

12^th International Congress on Endocrine Disorders, Tehran, Iran

November, 15^th 2018

Translational Research: Definition(s):
As a process

PCOS and Osteoporosis

Both …

• are major public health problems.
• are associated with high morbidity.
• have genetic bases and are affected by environmental factors.
• begin early in life; phenotypically present later.
• alter or result from alterations of various key hormones.

Osteoporosis: Resorption > Formation

1. Factors by Ob à Oc (vice versa)
2. Ocy interact directly with Ob
3. Ob-Ob contact
4. Adipocytes regulate both Ob and Oc
5. Canopy-forming osteomacs regulate Ob diff
6. TH cells get signals from the vicinity. Regulate Oc (+ or -)